2021 ADS Year in Review Webinar

Date & Time

Wednesday, December 8, 11AM EST / 8AM PST / 3PM GMT
Link to register: REGISTRATION

Year in Review Coordination

Coordinators: Mark Oldham and C. Adrian Austin

Hosts: Geriatric Workforce Enhancement Program at Johns Hopkins (Jane Marks) and Tullyvision (Michelle Powell)

Joint Provider: Sutter Health (Kerri Maya)


Members of the ADS Research Committee each nominated up to 6 studies they considered to be the best delirium research published during the 2020–2021 academic year, which was operationalized as articles having a DOI assigned from 6/1/20 through 8/31/21. The 24 nominated studies were divided into three categories as below (listed in alphabetical order). Each ADS Research Committee member was then assigned to one of the three categories, and they reviewed the studies in their assigned category for methodological rigor and impact using the scoring rubrics below. The studies with asterisks in the categories below received the highest average ratings and will be presented at the 2021 ADS Year in Review Webinar.

Scientific rigor: Is the methodology sound?
0 = Major design or bias concerns that undermine the validity of results
2 = Major design or bias concerns that cast serious doubt on the validity of results
4 = One or two major or multiple minor design or bias concerns that cast considerable doubt on the validity of results
6 = No major concerns but multiple minor design or bias concerns that cast some doubt the validity of results
8 = A few minor design or bias concerns that introduce no more than limited questions regarding the validity of results
10 =  Methodologically sound without design or bias concerns

Overall impact & importance: Does this study matter?
0 = Ignore it. No relevance or addition to field
2 = Extremely limited value. Only a niche group might find useful
4 = Some limited value. May be worthwhile to share with others, explore further
6 = Suggestive results. Warrants further discussion and/or study
8 = Promising results. Places new perspectives into translational or application cycle of research
10 = Conclusive. I will implement into my practice and share with a larger audience

Critical Care Studies

Presenter: Rishi Ganesan

Nominated Studies:

Duprey MS, Devlin JW, van der Hoeven JG, et al. Association Between Incident Delirium Treatment With Haloperidol and Mortality in Critically Ill Adults. Crit Care Med 2021;49:1303-11.

*Duprey MS, Dijkstra-Kersten SMA, Zaal IJ, et al. Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain. Am J Respir Crit Care Med 2021;204:566-72.

*Fiest KM, Soo A, Hee Lee C, et al. Long-Term Outcomes in ICU Patients with Delirium: A Population-based Cohort Study. Am J Respir Crit Care Med 2021;204:412-20.

*Hughes CG, Mailloux PT, Devlin JW, et al. Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis. N Engl J Med 2021;384:1424-36.

**Pun BT, Badenes R, Heras La Calle G, et al. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med 2021;9:239-50. (This study was rated among the top 3 in this category, but as it was featured prominently in the ADS Annual Meeting in June and presented by a study author we will present another study in its place for the Year in Review.)

Rengel KF, Hayhurst CJ, Jackson JC, et al. Motoric Subtypes of Delirium and Long-Term Functional and Mental Health Outcomes in Adults After Critical Illness. Crit Care Med 2021;49:e521-e32.

Silver G, Doyle H, Hegel E, et al. Association Between Pediatric Delirium and Quality of Life After Discharge. Crit Care Med 2020;48:1829-34.

Yamanashi T, Crutchley KJ, Wahba NE, et al. Evaluation of point-of-care thumb-size bispectral electroencephalography device to quantify delirium severity and predict mortality. British Journal of Psychiatry 2021:1-8.

Older Adult Studies

Presenter: Thiago J. Avelino-Silva

Nominated Studies:

Boockvar KS, Judon KM, Eimicke JP, Teresi JA, Inouye SK. Hospital Elder Life Program in Long-Term Care (HELP-LTC): A Cluster Randomized Controlled Trial. J Am Geriatr Soc 2020;68:2329-35.

Eeles E, Huang L, Dakin L, et al. Development and validation of an aetiology in delirium diagnostic support toolv. Age Ageing 2021;50:1402-5.

Fuchs S, Bode L, Ernst J, Marquetand J, von Kanel R, Bottger S. Delirium in elderly patients: Prospective prevalence across hospital services. Gen Hosp Psychiatry 2020;67:19-25.

*Madrigal C, Kim J, Jiang L, et al. Delirium and Functional Recovery in Patients Discharged to Skilled Nursing Facilities After Hospitalization for Heart Failure. JAMA Netw Open 2021;4:e2037968.

*Morandi A, Grossi E, Lucchi E, et al. The 4-DSD: A New Tool to Assess Delirium Superimposed on Moderate to Severe Dementia. J Am Med Dir Assoc 2021;22:1535-42 e3.

Pilling LC, Jones LC, Masoli JAH, et al. Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants. J Am Geriatr Soc 2021;69:365-72.

*Richardson SJ, Davis DHJ, Stephan BCM, et al. Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study. Age Ageing 2021;50:914-20.

Saito T, Toda H, Duncan GN, et al. Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients. J Psychiatr Res 2020;129:61-5.

Perioperative Care Studies

Presenter: Malissa Mulkey

Nominated Studies:

*Evered LA, Chan MTV, Han R, et al. Anaesthetic depth and delirium after major surgery: a randomised clinical trial. Br J Anaesth 2021;127:704-12.

Glynn K, McKenna F, Lally K, et al. How do delirium motor subtypes differ in phenomenology and contributory aetiology? a cross-sectional, multisite study of liaison psychiatry and palliative care patients. BMJ Open 2021;11:e041214.

*Gou RY, Hshieh TT, Marcantonio ER, et al. One-Year Medicare Costs Associated With Delirium in Older Patients Undergoing Major Elective Surgery. JAMA Surg 2021;156:430-42.

Hollinger A, Rust CA, Riegger H, et al. Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial. J Clin Anesth 2021;68:110099.

Huang Q, Li Q, Qin F, et al. Repeated Preoperative Intranasal Administration of Insulin Decreases the Incidence of Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Radical Gastrointestinal Surgery: A Randomized, Placebo-Controlled, Double-Blinded Clinical Study. Am J Geriatr Psychiatry 2021.

Kluger MT, Skarin M, Collier J, et al. Steroids to reduce the impact on delirium (STRIDE): a double-blind, randomised, placebo-controlled feasibility trial of pre-operative dexamethasone in people with hip fracture. Anaesthesia 2021;76:1031-41.

LaHue SC, Maselli J, Rogers S, et al. Outcomes Following Implementation of a Hospital-Wide, Multicomponent Delirium Care Pathway. J Hosp Med 2021;16:397-403.

*Turan A, Duncan A, Leung S, et al. Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial. Lancet 2020;396:177-85.